I wasn’t sure I was going to play in this sandbox again. I’m not really involved with volatile organic compound risk assessments anymore. I’ve expressed the opinion that what we need is not another toxicological assessment, but some action to replace the highest-exposure uses with some implementable alternatives. Outside of the workplace, perc isn’t terribly high on the list of environmental health hazards. But there is a framework in place for replacing it with lower-toxicity substitutes which could be template for other, more hazardous, compounds.
But instead, we have a draft toxicological assessment that is intended to provide toxicity values on EPA’s Integrated Risk Information System, which can then be used for risk assessments.
Just by eyeball, the estimated risks are similar to the last risk assessment conducted, done by Cal-EPA in the late 1990s. So, I’m not sure what’s been gained here – while it seems to be well-written, I’m wondering how this risk assessment is going to help us make faster or better decisions about managing PCE risks, given that it doesn’t say anything terribly different from what we knew a few years ago, and does not put much energy behind PCE risk-based decision making. In fairness, I should note that it’s not intended to be a policy document – its purpose is to make sure that good science and the right values are put up on IRIS.
At a high level, EPA’s assessment says that PCE is “likely to be carcinogenic” in humans by all routes of exposure and that the primary non-cancer toxic effects of PCE exposure in humans occur to the central nervous system, kidneys, liver and developing fetus. On the quantitative side, EPA judges the cancer potency of PCE to be slightly higher compared with its previous risk assessment, conducted in the late 1980s/early 1990s. Also, EPA judges PCE to pose slightly more of a non-cancer health risk, compared with previous assessments.
Once again, I’m wondering how we address what’s broken about risk assessment. I’m apparently not the only one:
However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment.
This is from the teaser from a forthcoming book from the National Academy of Sciences, Science and Decisions: Advancing Risk Assessment. This book promises to build off of the original framework for risk assessment, published in the book published in 1983 by the NAS, Risk Assessment in the Federal Government (also known as the Red Book). The Red Book established a framework for much of risk assessment as it is practiced today Science and Decisions, “embeds these concepts within a broader framework for risk-based decision-making.” Maybe it will contribute to “fixing” risk assessment. We’ll see. I’ve ordered a copy and will discuss it in a future post. Labels: environmental health policy, perchloroethylene, risk assessment